Project Title: The genomic architecture of human nucleolar organizer regions and its role in nucleolar biology
Supervisor: Prof Brian McStay
Duration: Funded for 4 years (Structured PhD), full-time.
Project description: Nucleoli form around arrays of genes that encode the major RNA component of ribosomes. These ribosomal gene arrays, known as nucleolar organizer regions (NORs) are located on the short-arms of five human chromosomes.
Contrary to popular belief the human genome sequence is incomplete and missing regions include the NOR bearing short arms of human chromosomes 13, 14, 15, 21 and 22. The successful candidate will join a Wellcome Trust funded team that aims to describe the genomic architecture surrounding human NORs (see recent publications Floutsakou et al. 2013. Genome Res 23: 2003-2012 and Grob et al. 2014. Genes Dev 28: 220-230).
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