A fully funded (48 months) PhD studentship is available at Department of Physics and Astronomy, Gent University, Belgium. The aim of this PhD project is study of effects of opening of hemichannels on onset of cardiac arrhythmias. Hemichannels are large conducting non-selective channels which opening has a significant effect on ionic fluxes through cardiac membrane.
The work will be performed in a close collaboration with a group which performs experimental measurements of properties of hemichannels in various conditions. On basis of these data a model of a hemichannel should be developed and integrated into an existing multiscale anatomical model of the human heart. This anatomical model will be used to study how opening of hemichannels affects the onset of cardiac arrhythmias and their dynamics.
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